Renin Activity, Plasma
Order Name
RENIN ACT
Test Number: 3802425
Revision Date 10/06/2023
Test Number: 3802425
Revision Date 10/06/2023
| Test Name | Methodology | LOINC Code |
|---|---|---|
|
Renin Activity, Plasma
|
Liquid Chromatography/Tandem Mass Spectrometry | 2915-7 |
| SPECIMEN REQUIREMENTS | ||||
|---|---|---|---|---|
| Specimen | Specimen Volume (min) | Specimen Type | Specimen Container | Transport Environment |
| Preferred | 1 mL (0.8) | Plasma | EDTA (Lavender Top) | Frozen |
| Instructions | Notes: 0.8 mL (Note: This volume Does NOT allow for repeat testing.) Specimen Type: Plasma, frozen Container Detail: Lavender-top (EDTA) tube Specimen Storage: FREEZE Specimen Collection: Draw blood into an EDTA tube. Keep tube at room temperature. Centrifuge at room temperature. Transfer the plasma into a plain screw cap pour off tube. Freeze immediately and maintain frozen until tested. IT IS CRITICAL THAT THE PLASMA BE TRANSFERRED AND FROZEN AS QUICKLY AS POSSIBLE TO PREVENT CRYOACTIVATION OF PROTEIN TO RENIN (WHICH RESULTS IN FALSELY ELEVATED RENIN LEVELS). To avoid delays in turnaround time when requesting multiple tests on frozen samples, PLEASE SUBMIT SEPARATE FROZEN SPECIMENS FOR EACH TEST REQUESTED. Special Instructions: The patient's posture at the time of collection should be noted (see Patient Preparation). Specimen Stability: Ambient: Unstable, Refrigerated : Unstable, Frozen: 14 days |
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| GENERAL INFORMATION | |
|---|---|
| Expected TAT | 3 - 7 days |
| Clinical Use | Renin is a proteolytic enzyme produced by the kidney in response to stimulation of renal beta-adrenergic receptors or by circulating catecholamines. Erect posture, exercise, sodium depletion, hemorrhage, and low cardiac output all increase renin secretion via one or more pathways. The measurement of plasma renin activity (PRA) is useful in evaluating hypertension. A normal or high PRA rules out primary aldosteronism, whereas a normal or low PRA helps rule out renal hypertension. Additionally, an elevated PRA may indicate renovascular hypertension due to renal artery stenosis. |
| Performing Labcorp Test Code | 002006 |
| Notes | The renin in plasma is allowed to act on the plasma's endogenous substrate, angiotensinogen producing angiotensin I. This is measured by liquid chromatography/mass spectrometry (LC/MS-MS). |
| CPT Code(s) | 84244 |
| Lab Section | Reference Lab |