Celiac Disease Antibody Panel
Order Name
CELIAC PNL
Test Number: 5537600
Revision Date 10/01/2022
Test Number: 5537600
Revision Date 10/01/2022
| Test Name | Methodology | LOINC Code |
|---|---|---|
|
Tissue Transglutaminase IgA (IgA anti-tTG)
|
Chemiluminescence Assay | 46128-5 |
|
Gliadin Deamidated Antibody, IgA
|
Chemiluminescence Assay | 63453-5 |
|
Gliadin Deamidated Antibody, IgG
|
Chemiluminescence Assay | 63459-2 |
|
Immunoglobulin IgA Quantitative
|
Turbidometric | 2458-8 |
| SPECIMEN REQUIREMENTS | ||||
|---|---|---|---|---|
| Specimen | Specimen Volume (min) | Specimen Type | Specimen Container | Transport Environment |
| Preferred | 1 mL (0.5 mL) | Serum | Clot Activator SST | Refrigerated |
| Instructions | Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Stability After separation from cells: Ambient 8 hours, Refrigerated 2 days, Frozen 30 days (avoid repeated freeze/thaw cycles). |
|||
| GENERAL INFORMATION | |
|---|---|
| Testing Schedule | Mon, Wed, Fri |
| Expected TAT | 2-5 Days |
| Clinical Use | Labcorp Oklahoma, Inc. recommends utilizing the celiac panel rather than the celiac analyzer because of the major improvements in the sensitivity and specificity of the IgA and IgG anti-gliadin assays. The celiac panel will now include quantitative IgA, the utilization of the synthetic gliadin-related deamidated peptides and human tissue transglutaminase (tTG). The utilization of the human tissue transglutaminase (tTG) and the synthetic gliadin-related deamidated peptide antigens in the EIA assay format for the detection of IgA anti-tTG, IgA anti-gliadin and IgG anti-gliadin have proven to be very sensitive and highly specific for celiac disease. |
| Notes | IgA deficiency is 10-15 times greater in patients with CD and therefore it would be important to reflex to IgG anti-tTG if the patient is IgA deficient and negative for IgG anti-gliadin. In patients with normal levels of IgA, any of the above serologic assays are suitable for following compliance to diet. A diet compliant patient will experience loss of the IgA anti-tTG, IgA anti-gliadin and/or IgG anti-gliadin after approximately 6 months. |
| CPT Code(s) | 83516x3; 82784 |
| Lab Section | Immunology - Serology |