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Ganglioside (Asialo-GM1, GM1, GM2, GD1a, GD1b, and GQ1b) Antibodies

Order Name GANLGI PN2
Test Number: 5565951
Revision Date 09/20/2015
Test Name Methodology LOINC Code
Asialo-GM1 Antibodies, IgG/IgM
Semi-Quantitative Enzyme-Linked Immunosorbent Assay 44737-5 
GM1 Antibodies, IgG/IgM
Semi-Quantitative Enzyme-Linked Immunosorbent Assay 63244-8 
GM2 Antibodies, IgG/IgM
Semi-Quantitative Enzyme-Linked Immunosorbent Assay 63249-7 
GD1a Antibodies, IgG/IgM
Semi-Quantitative Enzyme-Linked Immunosorbent Assay 48656-3 
GD1b Antibodies, IgG/IgM
Semi-Quantitative Enzyme-Linked Immunosorbent Assay 26870-6 
GQ1b Antibodies, IgG/IgM
Semi-Quantitative Enzyme-Linked Immunosorbent Assay 31674-5 
SPECIMEN REQUIREMENTS
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred 0.3 mL (0.1 mL) Serum Clot Activator SST Refrigerated
Instructions Separate serum from cells ASAP.
Unacceptable Conditions: Room temperature specimens. Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, hemolyzed , severely icteric, or lipemic specimens.
Stability: After separation from cells: Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 1 year
GENERAL INFORMATION
Testing Schedule Mon, Wed, Fri 
Expected TAT 2-5 Days  
Clinical Use Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) and the neutral glycolipid, asialo-GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. GD1a antibodies are associated with different variants of Guillain-Barre syndrome (GBS) particularly acute motor axonal neuropathy while GD1b antibodies are predominantly found in sensory ataxic neuropathy syndrome. Anti-GQ1b antibodies are seen in more than 80% of patients with Miller-Fisher syndrome and may be elevated in GBS patients with ophthalmoplegia. The role of isolated anti-GM2 antibodies is unknown. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease. 
Notes Reference Lab: ARUP
Test Code: 51033
Click Here to view information on the ARUP websit
CPT Code(s) 83516x6
Lab Section Reference Lab