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EGFR (Epidermal Growth Factor Receptor)
Mutation Analysis (TK Domain)

Test Number 9103095
Revision Date 11/16/2017
Test Name Methodology LOINC Code
EGFR (Epidermal Growth Factor Receptor)
Mutation Analysis (TK Domain)

Polymerase Chain Reaction  
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred Block Tissue Paraffin Block Room Temperature
Instructions Formalin fixed paraffin embedded tissue. Tissue source and block ID containing tumor are required on the requisition form.
Pathology permission is required for any alternate sample types.
Testing Schedule Tue and Thr 
Expected TAT 5-7 Days 
Clinical Use This is a DNA PCR amplification  test to identify patients with mutations in the TK domain of the EGFR gene (exons 18-21). With this information, physicians will be able to select those patients who are most likely to respond to targeted lung cancer therapy, including Iressa and Tarceva. Physicians can also use this information to predict drug resistance as identified by those patients who do not have those mutations or who have a mutation that confers resistance. 
CPT Code(s) (Pre-Authorization Required)
81235, plus G0452 for Molecular Pathology Interpretation, possible 88381 for Microdisection
Lab Section Molecular Diagnostic