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Maternal Serum Screen 4 (Quad Screen)

Order Name MAT SCR 4
Test Number: 3622300
Revision Date 11/15/2021
Test Name Methodology LOINC Code
Maternal Serum Screen 4 (Quad Screen)
Enzyme Immunoassay  
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred 3 mL (1) Serum Clot Activator SST Refrigerated
Instructions Specimen Stability: Ambient: 14 days; Refrigerated: 14 days; Frozen: 28 days;

The optimal gestational age for collection is 16-18 weeks.
The below information is required for accurate result interpretation:
  • Maternal date of birth:
  • Maternal weight:
  • Maternal race:
  • Maternal insulin-dependant diabetes status:
  • History of Neural Tube Defects:
  • History of Downs Syndrome:
  • Number of fetuses:
  • Estimated Date of Delivery (EDD):
  • Method of EDD determination:US/LMP/PE:
Testing Schedule Mon - Sat 
Expected TAT 4-6 Days  
Clinical Use The maternal serum biochemical quad screen is used for prenatal screening of Down syndrome (DS) (Trisomy 21), Edward's syndrome (Trisomy 18), and open neural tube defects (ONTD) and ventral abdominal wall defects. These risks can only be calculated for gestational ages between 15-22.9 weeks. The optimal collection time is at 16-18 weeks gestation.
Risk assessment for Neural Tube Defect (NTD), Down Syndrome (DS), and Trisomy 18 by calculating the MoM of the following components:
  • Serum Alpha-Fetoprotein (AFP)
  • Serum Human Chorionic Gonadotropin (hCG)
  • Serum Free Estriol (uE3)
  • Dimeric Inhibin A
Notes ?Reference Lab: Quest
Test Code: 30294
Click Here to view information on the Quest website.
CPT Code(s) 81511
Lab Section Reference Lab